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S Ylä-Herttuala Selected Research

Thymidine Kinase

4/2015Tomato thymidine kinase-based suicide gene therapy for malignant glioma--an alternative for Herpes Simplex virus-1 thymidine kinase.
12/2013Improved therapeutic effect on malignant glioma with adenoviral suicide gene therapy combined with temozolomide.
12/2012Increased invasion of malignant gliomas after 15-LO-1 and HSV-tk/ganciclovir combination gene therapy.
6/2008Water spin dynamics during apoptotic cell death in glioma gene therapy probed by T1rho and T2rho.
11/2000Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses.
9/2000Gene therapy for the treatment of peripheral vascular disease and coronary artery disease.
3/2000Herpes simplex virus thymidine kinase gene therapy in experimental rat BT4C glioma model: effect of the percentage of thymidine kinase-positive glioma cells on treatment effect, survival time, and tissue reactions.
1/2000Cardiovascular gene therapy.
1/2000Adenovirus-mediated herpes simplex thymidine kinase gene therapy for brain tumors.

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S Ylä-Herttuala Research Topics

Disease

12Neoplasms (Cancer)
01/2021 - 03/2000
10Atherosclerosis
06/2008 - 01/2000
8Glioma (Gliomas)
04/2015 - 01/2000
3Myocardial Ischemia (Ischemic Heart Diseases)
01/2021 - 01/2000
3Herpes Simplex
04/2015 - 01/2000
2Cardiovascular Diseases (Cardiovascular Disease)
01/2021 - 04/2012
2Neoplasm Metastasis (Metastasis)
11/2019 - 03/2001
2Hypercholesterolemia
01/2017 - 08/2001
2Virus Diseases (Viral Diseases)
01/2017 - 01/2015
2Ischemia
04/2012 - 09/2008
2Diabetic Retinopathy (Retinopathy, Diabetic)
04/2012 - 08/2009
2Type 2 Diabetes Mellitus (MODY)
08/2009 - 10/2000
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
08/2009 - 06/2008
2Pancreatic Neoplasms (Pancreatic Cancer)
01/2009 - 01/2000
2Vesicular Stomatitis
09/2008 - 02/2006
2Pathologic Constriction (Stenosis)
11/2002 - 01/2000
2Coronary Disease (Coronary Heart Disease)
09/2001 - 01/2000
2Vascular Diseases (Vascular Disease)
09/2000 - 01/2000
2Retinoblastoma (Glioblastoma, Retinal)
09/2000 - 01/2000
1Obstructive Sleep Apnea
01/2022
1Thrombosis (Thrombus)
10/2018
1Focal Infection
01/2015
1Carcinoma (Carcinomatosis)
01/2015
1Insulin Resistance
08/2014
1Weight Gain
08/2014
1Peripheral Arterial Occlusive Disease 1
04/2012
1Fibrosis (Cirrhosis)
12/2011
1Ovarian Neoplasms (Ovarian Cancer)
02/2011
1Coronary Artery Disease (Coronary Atherosclerosis)
05/2009
1Infections
06/2008
1Respiratory Tract Infections (Respiratory Tract Infection)
06/2008
1Heterotopic Ossification (Ectopic Ossification)
12/2007
1Severe combined immunodeficiency due to adenosine deaminase deficiency
01/2006
1Hyperplasia
11/2005
1Carcinogenesis
03/2001
1Breast Neoplasms (Breast Cancer)
03/2001

Drug/Important Bio-Agent (IBA)

13Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2021 - 01/2000
9Thymidine KinaseIBA
04/2015 - 01/2000
5Ganciclovir (Cytovene)FDA LinkGeneric
04/2015 - 03/2000
4AntibodiesIBA
07/2009 - 01/2000
3LipidsIBA
01/2017 - 03/2000
3EnzymesIBA
04/2015 - 08/2000
3Therapeutic UsesIBA
12/2013 - 01/2000
3Vascular Endothelial Growth Factor Receptor-3 (Flt 4)IBA
02/2011 - 02/2001
3Vascular Endothelial Growth Factor DIBA
08/2009 - 02/2001
3oxidized low density lipoproteinIBA
09/2001 - 01/2000
3Vascular Endothelial Growth Factor CIBA
03/2001 - 10/2000
2Transcription Factors (Transcription Factor)IBA
11/2019 - 01/2000
2Lipoproteins (Lipoprotein)IBA
01/2017 - 09/2001
2ProdrugsIBA
04/2015 - 12/2013
2Glucose (Dextrose)FDA LinkGeneric
08/2014 - 06/2008
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
08/2009 - 09/2000
2LigandsIBA
07/2009 - 12/2003
2Proteins (Proteins, Gene)FDA Link
02/2006 - 12/2003
2AutoantibodiesIBA
09/2001 - 01/2000
2Tissue Inhibitor of MetalloproteinasesIBA
09/2000 - 01/2000
2Nitric Oxide Synthase (NO Synthase)IBA
09/2000 - 01/2000
2Scavenger Receptors (Scavenger Receptor)IBA
03/2000 - 01/2000
1Amyloid (Amyloid Fibrils)IBA
01/2022
1RNA (Ribonucleic Acid)IBA
11/2019
1Apolipoproteins E (ApoE)IBA
01/2017
1Interferon Type IIBA
01/2015
1InterferonsIBA
01/2015
1ruxolitinibIBA
01/2015
1Vascular Endothelial Growth Factor BIBA
08/2014
1Temozolomide (Temodar)FDA LinkGeneric
12/2013
1SolutionsIBA
12/2012
1Liposomes (Liposome)IBA
04/2012
1AngiopoietinsIBA
02/2011
1TIE-2 Receptor (Receptor, TIE 2)IBA
02/2011
1Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA
02/2011
1Urokinase Plasminogen Activator ReceptorsIBA
09/2009
1Retinaldehyde (Retinal)IBA
08/2009
1Epidermal Growth Factor (EGF)IBA
07/2009
1Transferrin Receptors (Transferrin Receptor)IBA
07/2009
1omega-Chloroacetophenone (Mace)IBA
05/2009
1Silica GelIBA
01/2009
1Oxidants (Oxidizing Agents)IBA
09/2008
1Glycoproteins (Glycoprotein)IBA
09/2008
1Green Fluorescent ProteinsIBA
09/2008
1Tobacco Smoke Pollution (Passive Smoking)IBA
06/2008
1SmokeIBA
06/2008
1Peptides (Polypeptides)IBA
12/2007
1EndostatinsIBA
12/2007
1GTP-Binding Proteins (G-Protein)IBA
02/2006
1Adenosine DeaminaseIBA
01/2006
1baysilon (polydimethylsiloxane)IBA
11/2005
1CholesterolIBA
11/2005
1Vascular Endothelial Growth FactorsIBA
11/2005
1Biomarkers (Surrogate Marker)IBA
09/2001
1Superoxide DismutaseIBA
09/2001
1Nitric Oxide (Nitrogen Monoxide)FDA Link
08/2001
1AntioxidantsIBA
06/2001
1LDL Receptors (LDL Receptor)IBA
06/2001

Therapy/Procedure

6Therapeutics
01/2021 - 01/2000
2Stents
10/2018 - 11/2002
2Drug Therapy (Chemotherapy)
12/2013 - 02/2011
1Endovascular Procedures
10/2018
1Transplantation
01/2015
1Oncolytic Virotherapy
01/2015